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The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily
NovP is an S-adenosyl-L-methionine-dependent O-methyltransferase that catalyses the penultimate step in the biosynthesis of the aminocoumarin antibiotic novobiocin. Specifically, it methylates at the 4-OH of the noviose moiety, and the resultant methoxy group is important for the potency of the matu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2813333/ https://ncbi.nlm.nih.gov/pubmed/19857499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.045 |
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