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Mass spectrometric characterization of a three-enzyme tandem reaction for assembly and modification of the novobiocin skeleton

The tripartite scaffold of the natural product antibiotic novobiocin is assembled by the tandem action of novobiocin ligase (NovL) and novobiocic acid noviosyl transferase (NovM). The noviosyl ring of the tripartite scaffold is further decorated by a methyltransferase (NovP) and a carbamoyltransfera...

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Detalhes bibliográficos
Main Authors: Pi, Na, Meyers, Caren L. Freel, Pacholec, Michelle, Walsh, Christopher T., Leary, Julie A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC454160/
https://ncbi.nlm.nih.gov/pubmed/15218104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403526101
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