A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation

Mcph1 is mutated in autosomal recessive primary microcephaly and premature chromosome condensation (PCC) syndrome. Increased chromosome condensation is a common feature of cells isolated from patients afflicted with either disease. Normal cells depleted of Mcph1 also exhibit a PCC phenotype. Human M...

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Bibliographic Details
Main Authors: Richards, Mark W., Leung, Justin W.C., Roe, S. Mark, Chen, Junjie, Bayliss, Richard
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813331/
https://ncbi.nlm.nih.gov/pubmed/19925808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.029
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