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Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation

BACKGROUND: Mutations in multiple genes have been implicated in familial atrial fibrillation (AF), but the underlying mechanisms, and thus implications for therapy, remain ill-defined. METHODS AND RESULTS: Among 231 participants in the Vanderbilt AF Registry, we found a mutation in KCNQ1 (encoding t...

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Hlavní autoři: Abraham, Robert L, Yang, Tao, Blair, Marcia, Roden, Dan M, Darbar, Dawood
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813326/
https://ncbi.nlm.nih.gov/pubmed/19646991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.07.020
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