CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases

BACKGROUND: Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis and cancer. We determined the genetic variations of c-CBL, relationship to rec...

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Hauptverfasser: Tan, Yi-Hung Carol, Krishnaswamy, Soundararajan, Nandi, Suvobroto, Kanteti, Rajani, Vora, Sapana, Onel, Kenan, Hasina, Rifat, Lo, Fang-Yi, El-Hashani, Essam, Cervantes, Gustavo, Robinson, Matthew, Kales, Stephen C., Lipkowitz, Stanley, Karrison, Theodore, Sattler, Martin, Vokes, Everett E., Wang, Yi-Ching, Salgia, Ravi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813301/
https://ncbi.nlm.nih.gov/pubmed/20126411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008972
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