Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma

MET is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) and degraded by c-CBL E3-ubiquitin ligase. We investigated genetic variations of c-CBL in HNSCC and the relationship between c-CBL and MET expression. High MET, low c-CBL expression was detected in 10 cell lines and 73...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Rolle, Cleo E., Tan, Yi-Hung Carol, Seiwert, Tanguy Y., Vora, Sapana, Kanteti, Rajani, Hasina, Rifat, Carey, George B., Surati, Mosmi, Weichselbaum, Ralph R., Lingen, Mark W., Vokes, Everett E., Salgia, Ravi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386642/
https://ncbi.nlm.nih.gov/pubmed/27244893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9640
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