Production of cattle lacking prion protein

Prion diseases are caused by propagation of misfolded forms of the normal cellular prion protein PrP(C), such as PrP(BSE) in bovine spongiform encephalopathy (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans1. Disruption of PrP(C) expression in mice, a species that does not n...

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Detalhes bibliográficos
Main Authors: Richt, Jürgen A, Kasinathan, Poothappillai, Hamir, Amir N, Castilla, Joaquin, Sathiyaseelan, Thillai, Vargas, Francisco, Sathiyaseelan, Janaki, Wu, Hua, Matsushita, Hiroaki, Koster, Julie, Kato, Shinichiro, Ishida, Isao, Soto, Claudio, Robl, James M, Kuroiwa, Yoshimi
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2813193/
https://ncbi.nlm.nih.gov/pubmed/17195841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1271
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