Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis

We describe the application of a novel screening approach that combines automated yeast genetics, synthetic genetic array (SGA) analysis, and a high-content screening (HCS) system to examine mitotic spindle morphogenesis. We measured numerous spindle and cellular morphological parameters in thousand...

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Bibliographic Details
Main Authors: Vizeacoumar, Franco J., van Dyk, Nydia, S.Vizeacoumar, Frederick, Cheung, Vincent, Li, Jingjing, Sydorskyy, Yaroslav, Case, Nicolle, Li, Zhijian, Datti, Alessandro, Nislow, Corey, Raught, Brian, Zhang, Zhaolei, Frey, Brendan, Bloom, Kerry, Boone, Charles, Andrews, Brenda J.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2010
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812844/
https://ncbi.nlm.nih.gov/pubmed/20065090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200909013
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