The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage

We previously determined that Notch2, and not Notch1 was required for forming proximal nephron segments. The dominance of Notch2 may be conserved in humans, since Notch2 mutations occur in Alagille syndrome (ALGS) 2 patients, which includes renal complications. To test whether mutations in Notch1 co...

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Bibliografiske detaljer
Main Authors: Surendran, Kameswaran, Boyle, Scott, Barak, Hila, Kim, Mijin, Stromberski, Colin, McCright, Brent, Kopan, Raphael
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812695/
https://ncbi.nlm.nih.gov/pubmed/19914235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.11.017
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