Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

Chromosomal translocations are a hallmark of leukemia/lymphoma and also appear in solid tumors, but the underlying mechanism remains elusive. By establishing a cellular model that mimics the relative frequency of authentic translocation events without proliferation selection, we report mechanisms of...

Full description

Saved in:
Bibliographic Details
Main Authors: Lin, Chunru, Yang, Liuqing, Tanasa, Bogdan, Hutt, Kasey, Ju, Bong-gun, Ohgi, Kenny, Zhang, Jie, Rose, Dave, Fu, Xiang-Dong, Glass, Christopher K., Rosenfeld, Michael G.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812435/
https://ncbi.nlm.nih.gov/pubmed/19962179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.11.030
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items