Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion

The PD-1/PD-L pathway plays a major role in regulating T-cell exhaustion during chronic viral infections in animal models, as well as in humans, and blockade of this pathway can revive exhausted CD8(+) T cells. We examined the expression of PD-1 and its ligands, PD-L1 and PD-L2, in multiple tissues...

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Bibliographic Details
Main Authors: Blackburn, Shawn D., Crawford, Alison, Shin, Haina, Polley, Antonio, Freeman, Gordon J., Wherry, E. John
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812396/
https://ncbi.nlm.nih.gov/pubmed/19955307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01579-09
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