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Efficacy of Posaconazole against Three Clinical Aspergillus fumigatus Isolates with Mutations in the cyp51A Gene

The in vivo efficacy of posaconazole against 4 clinical Aspergillus fumigatus isolates with posaconazole MICs ranging from 0.03 to 16 mg/liter, as determined by CLSI method M38A, was assessed in a nonneutropenic murine model of disseminated aspergillosis. The underlying resistance mechanisms of the...

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Detalhes bibliográficos
Main Authors: Mavridou, Eleftheria, Brüggemann, Roger J. M., Melchers, Willem J. G., Mouton, Johan W., Verweij, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812170/
https://ncbi.nlm.nih.gov/pubmed/19917751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00931-09
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