Comparison of the Activity of a Human Simulated, High-Dose, Prolonged Infusion of Meropenem against Klebsiella pneumoniae Producing the KPC Carbapenemase versus That against Pseudomonas aeruginosa in an In Vitro Pharmacodynamic Model

We have previously demonstrated that a high-dose, prolonged-infusion meropenem regimen (2 g every 8 h [q8h]; 3-hour infusion) can achieve 40% free drug concentration above the MIC against Pseudomonas aeruginosa with MICs of ≤16 μg/ml. The objective of this experiment was to compare the efficacy of t...

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Detalhes bibliográficos
Main Authors: Bulik, Catharine C., Christensen, Henry, Li, Peng, Sutherland, Christina A., Nicolau, David P., Kuti, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812157/
https://ncbi.nlm.nih.gov/pubmed/19995927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01190-09
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