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In Vivo Efficacy of 1- and 2-Gram Human Simulated Prolonged Infusions of Doripenem against Pseudomonas aeruginosa

Doripenem is a new carbapenem antimicrobial with activity against a range of gram-negative organisms, including Pseudomonas aeruginosa. Previous animal studies have shown efficacy of a 500-mg dose of doripenem given as a 4-h infusion against P. aeruginosa with MICs of ≤4 μg/ml. The purpose of this s...

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Detalhes bibliográficos
Main Authors: Crandon, Jared L., Bulik, Catharine C., Nicolau, David P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764160/
https://ncbi.nlm.nih.gov/pubmed/19770286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00282-09
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