Blockade of X4-Tropic HIV-1 Cellular Entry by GSK812397, a Potent Noncompetitive CXCR4 Receptor Antagonist

GSK812397 is a potent entry inhibitor of X4-tropic strains of HIV-1, as demonstrated in multiple in vitro cellular assays (e.g., in peripheral blood mononuclear cells [PBMCs] and a viral human osteosarcoma [HOS] assay, mean 50% inhibitory concentrations [IC(50)s] ± standard errors of the means were...

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Main Authors: Jenkinson, Stephen, Thomson, Michael, McCoy, David, Edelstein, Mark, Danehower, Susan, Lawrence, Wendell, Wheelan, Pat, Spaltenstein, Andrew, Gudmundsson, Kristjan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812144/
https://ncbi.nlm.nih.gov/pubmed/19949058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01293-09
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