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Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

Copper is a cofactor for many cellular enzymes and transporters1. To load onto secreted and endomembrane cuproproteins, copper is translocated from the cytosol into membrane-bound organelles by ATP7A or ATP7B transporters, the genes for which are mutated in the copper imbalance syndromes, Menkes and...

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Sonraí Bibleagrafaíochta
Main Authors: Gangi Setty, Subba Rao, Tenza, Danièle, Sviderskaya, Elena V., Bennett, Dorothy C., Raposo, Graça, Marks, Michael S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812007/
https://ncbi.nlm.nih.gov/pubmed/18650808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07163
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