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Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes
Copper is a cofactor for many cellular enzymes and transporters1. To load onto secreted and endomembrane cuproproteins, copper is translocated from the cytosol into membrane-bound organelles by ATP7A or ATP7B transporters, the genes for which are mutated in the copper imbalance syndromes, Menkes and...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812007/ https://ncbi.nlm.nih.gov/pubmed/18650808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07163 |
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