Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion

INTRODUCTION: High mobility group box nuclear protein 1 (HMGB1) is a DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like-receptor 4 (TLR4) and the receptor for the advanced g...

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Main Authors: Cohen, Mitchell J, Brohi, Karim, Calfee, Carolyn S, Rahn, Pamela, Chesebro, Brian B, Christiaans, Sarah C, Carles, Michel, Howard, Marybeth, Pittet, Jean-François
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811903/
https://ncbi.nlm.nih.gov/pubmed/19887013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8152
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