Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumonia

INTRODUCTION: Aminoglycosides aerosolization might achieve better diffusion into the alveolar compartment than intravenous use. The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration into the alveolar epithelial lining fluid (ELF) using a new vibrating mesh ne...

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Detalhes bibliográficos
Main Authors: Luyt, Charles-Edouard, Clavel, Marc, Guntupalli, Kalpalatha, Johannigman, Jay, Kennedy, John I, Wood, Christopher, Corkery, Kevin, Gribben, Dennis, Chastre, Jean
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811890/
https://ncbi.nlm.nih.gov/pubmed/20003269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc8206
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