Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-Inducible Factor-1α and -2α in Colon Cancer

KRAS and BRAF mutations are frequently observed in human colon cancers. These mutations occur in a mutually exclusive manner, and each is associated with distinctive biological features. We previously demonstrated that K-ras can interact with hypoxia to activate multiple signaling pathways. Many hyp...

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Main Authors: Kikuchi, Hirotoshi, Pino, Maria S., Zeng, Min, Shirasawa, Senji, Chung, Daniel C.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811371/
https://ncbi.nlm.nih.gov/pubmed/19843849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2213
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