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Hypoxia Activates the K-Ras Proto-Oncogene to Stimulate Angiogenesis and Inhibit Apoptosis in Colon Cancer Cells

The KRAS proto-oncogene plays a key role in the development of many human tumors and is commonly activated by somatic mutation or signaling through specific growth factor receptors. However, the interaction between the micro-environment and K-ras activity has not been defined. Hypoxia invariably dev...

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Bibliografski detalji
Glavni autori: Zeng, Min, Kikuchi, Hirotoshi, Pino, Maria S., Chung, Daniel C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881039/
https://ncbi.nlm.nih.gov/pubmed/20532039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010966
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