PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been identified. We showed that a transmembrane protein tyrosine phosphatase, PTPσ, binds with high affinity to neural CSPGs. Binding involves the ch...

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Hlavní autoři: Shen, Yingjie, Tenney, Alan P., Busch, Sarah A., Horn, Kevin P., Cuascut, Fernando X., Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811318/
https://ncbi.nlm.nih.gov/pubmed/19833921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178310
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