Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

BACKGROUND: Traumatic spinal cord injury (SCI) results in upregulation of chondroitin sulfate proteoglycans (CSPGs) by reactive glia that impedes repair and regeneration in the spinal cord. Degradation of CSPGs is known to be beneficial in promoting endogenous repair mechanisms including axonal spro...

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Bibliografski detalji
Izdano u:J Neuroinflammation
Glavni autori: Dyck, Scott, Kataria, Hardeep, Alizadeh, Arsalan, Santhosh, Kallivalappil T., Lang, Bradley, Silver, Jerry, Karimi-Abdolrezaee, Soheila
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861616/
https://ncbi.nlm.nih.gov/pubmed/29558941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1128-2
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