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Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability

The effects of lifelong, moderate excess release of glutamate (Glu) in the CNS have not been previously characterized. We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release in the CNS by introducing the gene for glutamate dehydrogenase 1 (Glud1) under the control of the ne...

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書誌詳細
主要な著者: Bao, Xiaodong, Pal, Ranu, Hascup, Kevin N., Wang, Yongfu, Wang, Wen-Tung, Xu, Wenhao, Hui, Dongwei, Agbas, Abdulbaki, Wang, Xinkun, Michaelis, Mary L., Choi, In-Young, Belousov, Andrei B., Gerhardt, Greg A., Michaelis, Elias K.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811066/
https://ncbi.nlm.nih.gov/pubmed/19890003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4413-09.2009
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