Transgenic Expression of Glud1 (Glutamate Dehydrogenase 1) in Neurons: In Vivo Model of Enhanced Glutamate Release, Altered Synaptic Plasticity, and Selective Neuronal Vulnerability

The effects of lifelong, moderate excess release of glutamate (Glu) in the CNS have not been previously characterized. We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release in the CNS by introducing the gene for glutamate dehydrogenase 1 (Glud1) under the control of the ne...

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Autors principals: Bao, Xiaodong, Pal, Ranu, Hascup, Kevin N., Wang, Yongfu, Wang, Wen-Tung, Xu, Wenhao, Hui, Dongwei, Agbas, Abdulbaki, Wang, Xinkun, Michaelis, Mary L., Choi, In-Young, Belousov, Andrei B., Gerhardt, Greg A., Michaelis, Elias K.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811066/
https://ncbi.nlm.nih.gov/pubmed/19890003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4413-09.2009
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