Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype

AIMS: The aim was to determine the pharmacokinetics of voriconazole after a single oral dose in comparison with intravenous (i.v.) administration in healthy individuals stratified according to the cytochrome P450 (CYP) 2C19 genotype. In addition, the possible metabolic pathways and their modulation...

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Bibliographic Details
Main Authors: Scholz, Ina, Oberwittler, Heike, Riedel, Klaus-Dieter, Burhenne, Jürgen, Weiss, Johanna, Haefeli, Walter E, Mikus, Gerd
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2009
Subjects:
Pharmacokinetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810802/
https://ncbi.nlm.nih.gov/pubmed/20002085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03534.x
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