Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole

AIMS: To investigate in vivo the influence of the potent CYP2C19 and CYP3A4 inhibitor voriconazole on the pharmacokinetics and analgesic effects of tilidine. METHODS: Sixteen healthy volunteers received voriconazole (400 mg) or placebo together with a single oral dose of tilidine (100 mg). Blood sam...

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Detalhes bibliográficos
Main Authors: Grün, Barbara, Krautter, Stefanie, Riedel, Klaus-Dieter, Mikus, Gerd
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Drug Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791977/
https://ncbi.nlm.nih.gov/pubmed/19916995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03498.x
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