Up-regulation of PD-L1 on Monocytes and Dendritic Cells by HIV-1 derived TLR Ligands

Increased PD-L1 expression has been reported in HIV-1-infected individuals, but the mechanisms leading to PD-L1-up-regulation remain to be elucidated. Here we demonstrate that HIV-1-derived TLR7/8 ligands can induce MyD88-dependent up-regulation of PD-L1 on pDCs, mDCs and monocytes. These data sugge...

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Главные авторы: Meier, Angela, Bagchi, Aranya, Sidhu, Harlyn K., Alter, Galit, Suscovich, Todd J., Kavanagh, Daniel G., Streeck, Hendrik, Brockman, Mark A., LeGall, Sylvie, Hellman, Judith, Altfeld, Marcus
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810187/
https://ncbi.nlm.nih.gov/pubmed/18317010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3282f4de23
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