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Duplex Formation at the 5’ end Affects Quadruplex Conformation of the Human Telomeric Repeat Overhang in Sodium but not in Potassium

Human telomeres contain numerous copies of (TTAGGG)(n)•(AATCCC)(n) repeated sequence with multiple TTAGGG repeats in 3’ single-stranded overhangs. Single-stranded oligonucleotides consisting of four TTAGGG repeats can fold into various intramolecular quadruplexes structures stabilized by quartets of...

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Detalhes bibliográficos
Main Authors: Gaynutdinov, Timur I., Brown, Patrick, Neumann, Ronald D., Panyutin, Igor G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810119/
https://ncbi.nlm.nih.gov/pubmed/19856972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901063g
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