Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans and have been shown to contribute to cancer development. Here, we have isolated...

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Main Authors: Chalmin, Fanny, Ladoire, Sylvain, Mignot, Grégoire, Vincent, Julie, Bruchard, Mélanie, Remy-Martin, Jean-Paul, Boireau, Wilfrid, Rouleau, Alain, Simon, Benoit, Lanneau, David, De Thonel, Aurélie, Multhoff, Gabriele, Hamman, Arlette, Martin, François, Chauffert, Bruno, Solary, Eric, Zitvogel, Laurence, Garrido, Carmen, Ryffel, Bernhard, Borg, Christophe, Apetoh, Lionel, Rébé, Cédric, Ghiringhelli, François
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810085/
https://ncbi.nlm.nih.gov/pubmed/20093776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40483
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