Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic neurons in vitro, the physiological and pathophysiological roles of this remain unknown. During congestive heart failure (CHF), sympathetic neural tone is upregulated, but there is a...

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Autores principales: Kanazawa, Hideaki, Ieda, Masaki, Kimura, Kensuke, Arai, Takahide, Kawaguchi-Manabe, Haruko, Matsuhashi, Tomohiro, Endo, Jin, Sano, Motoaki, Kawakami, Takashi, Kimura, Tokuhiro, Monkawa, Toshiaki, Hayashi, Matsuhiko, Iwanami, Akio, Okano, Hideyuki, Okada, Yasunori, Ishibashi-Ueda, Hatsue, Ogawa, Satoshi, Fukuda, Keiichi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2010
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810079/
https://ncbi.nlm.nih.gov/pubmed/20051627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39778
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