Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic neurons in vitro, the physiological and pathophysiological roles of this remain unknown. During congestive heart failure (CHF), sympathetic neural tone is upregulated, but there is a...

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Bibliografiska uppgifter
Huvudupphovsmän: Kanazawa, Hideaki, Ieda, Masaki, Kimura, Kensuke, Arai, Takahide, Kawaguchi-Manabe, Haruko, Matsuhashi, Tomohiro, Endo, Jin, Sano, Motoaki, Kawakami, Takashi, Kimura, Tokuhiro, Monkawa, Toshiaki, Hayashi, Matsuhiko, Iwanami, Akio, Okano, Hideyuki, Okada, Yasunori, Ishibashi-Ueda, Hatsue, Ogawa, Satoshi, Fukuda, Keiichi
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810079/
https://ncbi.nlm.nih.gov/pubmed/20051627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39778
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