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Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic neurons in vitro, the physiological and pathophysiological roles of this remain unknown. During congestive heart failure (CHF), sympathetic neural tone is upregulated, but there is a...

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Detalhes bibliográficos
Main Authors: Kanazawa, Hideaki, Ieda, Masaki, Kimura, Kensuke, Arai, Takahide, Kawaguchi-Manabe, Haruko, Matsuhashi, Tomohiro, Endo, Jin, Sano, Motoaki, Kawakami, Takashi, Kimura, Tokuhiro, Monkawa, Toshiaki, Hayashi, Matsuhiko, Iwanami, Akio, Okano, Hideyuki, Okada, Yasunori, Ishibashi-Ueda, Hatsue, Ogawa, Satoshi, Fukuda, Keiichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810079/
https://ncbi.nlm.nih.gov/pubmed/20051627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39778
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