Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents

Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic neurons in vitro, the physiological and pathophysiological roles of this remain unknown. During congestive heart failure (CHF), sympathetic neural tone is upregulated, but there is a...

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Détails bibliographiques
Auteurs principaux: Kanazawa, Hideaki, Ieda, Masaki, Kimura, Kensuke, Arai, Takahide, Kawaguchi-Manabe, Haruko, Matsuhashi, Tomohiro, Endo, Jin, Sano, Motoaki, Kawakami, Takashi, Kimura, Tokuhiro, Monkawa, Toshiaki, Hayashi, Matsuhiko, Iwanami, Akio, Okano, Hideyuki, Okada, Yasunori, Ishibashi-Ueda, Hatsue, Ogawa, Satoshi, Fukuda, Keiichi
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2810079/
https://ncbi.nlm.nih.gov/pubmed/20051627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39778
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