Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette

OBJECTIVE: In part, activation of invariant natural killer T (iNKT)-cells with the superagonist α-galactosylceramide (α-GalCer) inhibits the development of T-cell–mediated autoimmune type 1 diabetes in NOD mice by inducing the downstream differentiation of antigen-presenting dendritic cells (DCs) to...

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Main Authors: Driver, John P., Scheuplein, Felix, Chen, Yi-Guang, Grier, Alexandra E., Wilson, S. Brian, Serreze, David V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809954/
https://ncbi.nlm.nih.gov/pubmed/19903740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1116
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