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Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

The ubiquitin-proteasome and lysosome-autophagy pathways are the two major intracellular protein degradation systems that work cooperatively to maintain homeostasis. Proteasome inhibitors (PIs) have clinical activity in hematological tumors, and inhibitors of autophagy are also being evaluated as po...

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Detalhes bibliográficos
Main Authors: Zhu, Keyi, Dunner, Kenneth, McConkey, David J
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2809784/
https://ncbi.nlm.nih.gov/pubmed/19881538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.343
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