EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

Epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have been widely used in patients with non-small-cell lung cancer. Unfortunately, the efficacy of EGFR-TKIs is limited because of natural and acquired resistance. As a novel cytoprotective mechanism for tumor cell to...

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Detalhes bibliográficos
Main Authors: Han, Weidong, Pan, Hongming, Chen, Yan, Sun, Jie, Wang, Yanshan, Li, Jing, Ge, Weiting, Feng, Lifeng, Lin, Xiaoying, Wang, Xiaojia, Wang, Xian, Jin, Hongchuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107207/
https://ncbi.nlm.nih.gov/pubmed/21655094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018691
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