Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target
Synthetic C peptides, corresponding to the C helix of the HIV type 1 (HIV-1) gp41 envelope protein, are potent inhibitors of HIV-1 membrane fusion. One such peptide is in clinical trials. The crystal structure of the gp41 core, in its proposed fusion-active conformation, is a trimer of helical hairp...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC28092/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9861018/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.26.15613 |
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