The Lever Arm Effects a Mechanical Asymmetry of the Myosin-V-Actin Bond

Myosin-V is a two-headed molecular motor taking multiple ATP-dependent steps toward the plus end (forward) of actin filaments. At high mechanical loads, the motor processively steps toward the minus end (backward) even in the absence of ATP, whereas analogous forward steps cannot be induced. The det...

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Bibliografiske detaljer
Main Authors: Gebhardt, J. Christof M., Ökten, Zeynep, Rief, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2010
Fag:
Muscle, Motility, and Motor Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808492/
https://ncbi.nlm.nih.gov/pubmed/20338849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.10.017
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