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Microtubules Regulate Migratory Polarity through Rho/ROCK Signaling in T Cells

BACKGROUND: Migrating leukocytes normally have a polarized morphology with an actin-rich lamellipodium at the front and a uropod at the rear. Microtubules (MTs) are required for persistent migration and chemotaxis, but how they affect cell polarity is not known. METHODOLOGY/PRINCIPAL FINDINGS: Here...

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Sonraí Bibleagrafaíochta
Main Authors: Takesono, Aya, Heasman, Sarah J., Wojciak-Stothard, Beata, Garg, Ritu, Ridley, Anne J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808253/
https://ncbi.nlm.nih.gov/pubmed/20098744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008774
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