Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

Memantine is an N-methyl-d-aspartate receptor antagonist that is approved for the treatment of moderate to severe Alzheimer’s disease (AD). In this study, three groups of triple-transgenic (3xTg-AD) mice with differing levels of AD-like pathology (6, 9, and 15 months of age) were treated for 3 month...

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Hoofdauteurs: Martinez-Coria, Hilda, Green, Kim N., Billings, Lauren M., Kitazawa, Masashi, Albrecht, Miriam, Rammes, Gerhard, Parsons, Chris G., Gupta, Sandeep, Banerjee, Pradeep, LaFerla, Frank M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808092/
https://ncbi.nlm.nih.gov/pubmed/20042680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090452
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