ABSENCE OF OLIGODENDROGLIAL GLUCOSYLCERAMIDE SYNTHESIS DOES NOT RESULT IN CNS MYELIN ABNORMALITIES OR ALTER THE DYSMYELINATING PHENOTYPE OF CGT-DEFICIENT MICE

To examine the function of glycosphingolipids (GSLs) in oligodendrocytes, the myelinating cells of the central nervous system (CNS), mice were generated that lack oligodendroglial expression of UDP-glucose ceramide glucosyltransferase (encoded by Ugcg). These mice (Ugcg(flox/flox);Cnp/Cre) did not s...

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Hauptverfasser: Saadat, Laleh, Dupree, Jeffrey L., Kilkus, John, Han, Xianlin, Traka, Maria, Proia, Richard L., Dawson, Glyn, Popko, Brian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807477/
https://ncbi.nlm.nih.gov/pubmed/19705459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20930
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