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The ClC-3 Cl(−)/H(+) Antiporter Becomes Uncoupled at Low Extracellular pH

Adenovirus expressing ClC-3 (Ad-ClC-3) induces Cl(−)/H(+) antiport current (I(ClC-3)) in HEK293 cells. The outward rectification and time dependence of I(ClC-3) closely resemble an endogenous HEK293 cell acid-activated Cl(−) current (ICl(acid)) seen at extracellular pH ≤ 5.5. ICl(acid) was present i...

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Main Authors: Matsuda, James J., Filali, Mohammed S., Collins, Malia M., Volk, Kenneth A., Lamb, Fred S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807314/
https://ncbi.nlm.nih.gov/pubmed/19926787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018002
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