Crystal Structures of Progressive Ca(2+) Binding States of the Ca(2+) Sensor Ca(2+) Binding Domain 1 (CBD1) from the CALX Na(+)/Ca(2+) Exchanger Reveal Incremental Conformational Transitions

Na(+)/Ca(2+) exchangers (NCX) constitute a major Ca(2+) export system that facilitates the re-establishment of cytosolic Ca(2+) levels in many tissues. Ca(2+) interactions at its Ca(2+) binding domains (CBD1 and CBD2) are essential for the allosteric regulation of Na(+)/Ca(2+) exchange activity. The...

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Detalhes bibliográficos
Main Authors: Wu, Mousheng, Le, Hoa Dinh, Wang, Meitian, Yurkov, Vladimir, Omelchenko, Alexander, Hnatowich, Mark, Nix, Jay, Hryshko, Larry V., Zheng, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807312/
https://ncbi.nlm.nih.gov/pubmed/19815561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.059162
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