Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

Nonribosomal peptide synthetases (NRPSs) are large, multidomain proteins that are involved in the biosynthesis of an array of secondary metabolites. We report the structure of the third adenylation domain from the siderophore-synthesizing NRPS, SidN, from the endophytic fungus Neotyphodium lolii. Th...

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Autors principals: Lee, T. Verne, Johnson, Linda J., Johnson, Richard D., Koulman, Albert, Lane, Geoffrey A., Lott, J. Shaun, Arcus, Vickery L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807299/
https://ncbi.nlm.nih.gov/pubmed/19923209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071324
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