Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

Nonribosomal peptide synthetases (NRPSs) are large, multidomain proteins that are involved in the biosynthesis of an array of secondary metabolites. We report the structure of the third adenylation domain from the siderophore-synthesizing NRPS, SidN, from the endophytic fungus Neotyphodium lolii. Th...

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Main Authors: Lee, T. Verne, Johnson, Linda J., Johnson, Richard D., Koulman, Albert, Lane, Geoffrey A., Lott, J. Shaun, Arcus, Vickery L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807299/
https://ncbi.nlm.nih.gov/pubmed/19923209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.071324
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