Mechanism of Action of an Imidopiperidine Inhibitor of Human Polynucleotide Kinase/Phosphatase

The small molecule, 2-(1-hydroxyundecyl)-1-(4-nitrophenylamino)-6-phenyl-6,7a-dihydro-1H-pyrrolo[3,4-b]pyridine-5,7(2H,4aH)-dione (A12B4C3), is a potent inhibitor of the phosphatase activity of human polynucleotide kinase/phosphatase (PNKP) in vitro. Kinetic analysis revealed that A12B4C3 acts as a...

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Autors principals: Freschauf, Gary K., Mani, Rajam S., Mereniuk, Todd R., Fanta, Mesfin, Virgen, Caesar A., Dianov, Grigory L., Grassot, Jean-Marie, Hall, Dennis G., Weinfeld, Michael
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807293/
https://ncbi.nlm.nih.gov/pubmed/19940137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.055764
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