Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) remains poor, in part from a lack of therapeutic targets. We identified the type I cytokine receptor subunit CRLF2 in a functional screen for B-ALL–derived mRNA transcripts that can substitute for IL3 signaling. We d...

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Autors principals: Yoda, Akinori, Yoda, Yuka, Chiaretti, Sabina, Bar-Natan, Michal, Mani, Kartik, Rodig, Scott J., West, Nathan, Xiao, Yun, Brown, Jennifer R., Mitsiades, Constantine, Sattler, Martin, Kutok, Jeffrey L., DeAngelo, Daniel J., Wadleigh, Martha, Piciocchi, Alfonso, Dal Cin, Paola, Bradner, James E., Griffin, James D., Anderson, Kenneth C., Stone, Richard M., Ritz, Jerome, Foà, Robin, Aster, Jon C., Frank, David A., Weinstock, David M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806782/
https://ncbi.nlm.nih.gov/pubmed/20018760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911726107
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