Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2

Approximately 10% of B-cell acute lymphoblastic leukemias (B-ALLs) overexpress the cytokine receptor subunit CRLF2, which may confer a poor prognosis. CRLF2 binds its ligand thymic stromal lymphopoietin (TSLP) as a heterodimer with IL7R. Subsets of CRLF2-overexpressing B-ALLs also have a gain-of-fun...

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Main Authors: van Bodegom, Diederik, Zhong, Jun, Kopp, Nadja, Dutta, Chaitali, Kim, Min-Sik, Bird, Liat, Weigert, Oliver, Tyner, Jeffrey, Pandey, Akhilesh, Yoda, Akinori, Weinstock, David M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466966/
https://ncbi.nlm.nih.gov/pubmed/22915648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-413252
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