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Amplified RNA degradation in T7-amplification methods results in biased microarray hybridizations

BACKGROUND: The amplification of RNA with the T7-System is a widely used technique for obtaining increased amounts of RNA starting from limited material. The amplified RNA (aRNA) can subsequently be used for microarray hybridizations, warranting sufficient signal for image analysis. We describe here...

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Détails bibliographiques
Auteurs principaux: Spiess, Andrej-Nikolai, Mueller, Nadine, Ivell, Richard
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC280674/
https://ncbi.nlm.nih.gov/pubmed/14606961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-4-44
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