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Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin
Blood coagulation in humans requires the activity of vitamin K epoxide reductase (VKOR), the target of the anticoagulant warfarin (Coumadin). Bacterial homologs of VKOR were recently found to participate in a pathway leading to disulfide bond formation in secreted proteins of many bacteria. Here we...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806739/ https://ncbi.nlm.nih.gov/pubmed/20018758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912952107 |
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