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Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin

Blood coagulation in humans requires the activity of vitamin K epoxide reductase (VKOR), the target of the anticoagulant warfarin (Coumadin). Bacterial homologs of VKOR were recently found to participate in a pathway leading to disulfide bond formation in secreted proteins of many bacteria. Here we...

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Detalhes bibliográficos
Main Authors: Dutton, Rachel J., Wayman, April, Wei, Jun-Rong, Rubin, Eric J., Beckwith, Jon, Boyd, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806739/
https://ncbi.nlm.nih.gov/pubmed/20018758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912952107
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